Aberrant translation regulated by METTL1/WDR4-mediated tRNA N7-methylguanosine modification drives head and neck squamous cell carcinoma progression.

ABSTRACT:

Background

Cancer cells selectively promote the translation of oncogenic transcripts to stimulate cancer progression. Although growing evidence has revealed that tRNA modifications and related genes participate in this process, their roles in head and neck squamous cell carcinoma (HNSCC) remain largely uncharacterized. Here, we sought to investigate the function and mechanisms of the transfer RNA (tRNA) N7-methylguanosine (m⁷ G) modification in regulating the occurrence and development of HNSCC.

Methods

Cell lost-of-function and gain-of-function assays, xenograft models, conditional knockout and knockin mouse models were used to study the physiological functions of tRNA m⁷ G modification in HNSCC tumorigenesis. tRNA modification and expression profiling

SUBMITTER: Chen J 

PROVIDER: S-EPMC8923133 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature