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A LINC between the nucleus and the cytoskeleton takes form(in).


ABSTRACT: Dynamic nuclear positioning requires the formation of robust connections between the cytoskeleton and components of the LINC complex, a protein assembly that spans the nuclear envelope. A new study by Lim et al. (2021) reveals the mechanism of association between the LINC complex proteins Nesprin-1/2 Giant and the cytoplasmic formin FHOD1.

SUBMITTER: Zweifel ME 

PROVIDER: S-EPMC8923135 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature

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A LINC between the nucleus and the cytoskeleton takes form(in).

Zweifel Mark E ME   Courtemanche Naomi N  

Structure (London, England : 1993) 20210601 6


Dynamic nuclear positioning requires the formation of robust connections between the cytoskeleton and components of the LINC complex, a protein assembly that spans the nuclear envelope. A new study by Lim et al. (2021) reveals the mechanism of association between the LINC complex proteins Nesprin-1/2 Giant and the cytoplasmic formin FHOD1. ...[more]

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