Palmarumycin P3 Reverses Mrr1-Mediated Azole Resistance by Blocking the Efflux Pump Mdr1.
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ABSTRACT:
SUBMITTER: Song M
PROVIDER: S-EPMC8923160 | biostudies-literature | 2022 Mar
REPOSITORIES: biostudies-literature
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Palmarumycin P3 Reverses Mrr1-Mediated Azole Resistance by Blocking the Efflux Pump Mdr1.
Song Minghui M Zhang Ming M Lu Jinghui J Xie Fei F Song Jintong J Luan Xiaoyi X Hou Xuben X Lou Hongxiang H Chang Wenqiang W
Antimicrobial agents and chemotherapy 20220118 3
Palmarumycin P3 (PP3) reduces fluconazole-induced <i>MDR1</i> transcription to reverse azole resistance in clinical <i>Candida</i> strains. Here, we demonstrated that PP3 restores the susceptibility to several antifungal drugs for Candida albicans strains with gain-of-function mutations in the transcription factor Mrr1. In addition, PP3 inhibits the efflux of Mdr1 substrates by C. albicans strains harboring hyperactive <i>MRR1</i> alleles. Molecular docking revealed that PP3 is a potential Mdr1 ...[more]
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