In Vitro Activity of Cefepime-Taniborbactam against Carbapenemase-Producing Enterobacterales and Pseudomonas aeruginosa Isolates Recovered in Spain.

ABSTRACT: Novel β-lactam-β-lactamase inhibitor combinations currently approved for clinical use are poorly active against metallo-β-lactamase (MBL)-producing strains. We evaluated the in vitro activity of cefepime-taniborbactam (FTB [formerly cefepime-VNRX-5133]) and comparator agents against carbapenemase-producing Enterobacterales (n = 247) and carbapenem-resistant Pseudomonas species (n = 170) clinical isolates prospectively collected from different clinical origins in patients admitted to 8 Spanish hospitals. FTB was the most active agent in both Enterobacterales (97.6% MIC_FTB, ≤8/4 mg/L) and Pseudomonas (67.1% MIC_FTB, ≤8/4 mg/L) populations. The MIC_FTB was >8 mg/L in 6/247 (2.4%) Enterobacterales isolates (3 KPC-producin

SUBMITTER: Hernandez-Garcia M 

PROVIDER: S-EPMC8923209 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature