Association between low levels of HIV-1 DNA and HLA class I molecules in chronic HIV-1 infection.

ABSTRACT:

Background

HLA-B27 and -B57 were found in people with low levels of HIV-1 DNA, suggesting that HLA class I molecules may influence the size of HIV-1 reservoir. Aim of the study was to explore the association between HLA class I molecules and HIV-1 DNA in people with chronic HIV-1 infection.

Methods

Post-hoc analysis of the APACHE trial, on adults with chronic HIV-1 infection, prolonged suppressive antiretroviral therapy and good immunological profile. HIV-1 DNA was quantified in peripheral blood mononuclear cells (PBMCs); HLA-A, -B and -C were tested on genomic DNA. Crude odds ratios (OR) with their respective 95% Wald confidence intervals (95% CIs) were estimated by univariable logistic regression for HLAs with a p-value <0.10.

Results

We found 78 and 18 patients wit

SUBMITTER: Muccini C 

PROVIDER: S-EPMC8923435 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature