Zika virus disrupts gene expression in human myoblasts and myotubes: Relationship with susceptibility to infection.

ABSTRACT: The tropism of Zika virus (ZIKV) has been described in the nervous system, blood, placenta, thymus, and skeletal muscle. We investigated the mechanisms of skeletal muscle susceptibility to ZIKV using an in vitro model of human skeletal muscle myogenesis, in which myoblasts differentiate into myotubes. Myoblasts were permissive to ZIKV infection, generating productive viral particles, while myotubes controlled ZIKV replication. To investigate the underlying mechanisms, we used gene expression profiling. First, we assessed gene changes in myotubes compared with myoblasts in the model without infection. As expected, we observed an increase in genes and pathways related to the contractile muscle system in the myotubes, a reduction in processes linked to proliferation, migration and cytokine pr

SUBMITTER: Riederer I 

PROVIDER: S-EPMC8923442 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature