Unknown

Dataset Information

0

Molecular basis of AmpC hyperproduction in clinical isolates of Escherichia coli.

ABSTRACT: DNA sequencing data showed that five clinical isolates of Escherichia coli with reduced susceptibility to ceftazidime, ceftriaxone, and cefotaxime contain an ampC gene that is preceded by a strong promoter. Transcription from the strong promoter was 8- to 18-fold higher than that from the promoter from a susceptible isolate. RNA studies showed that mRNA stability does not play a role in the control of AmpC synthesis.

SUBMITTER: Nelson EC 

PROVIDER: S-EPMC89235 | biostudies-literature | 1999 Apr

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

Molecular basis of AmpC hyperproduction in clinical isolates of Escherichia coli.

Nelson E C EC   Elisha B G BG  

Antimicrobial agents and chemotherapy 19990401 4

DNA sequencing data showed that five clinical isolates of Escherichia coli with reduced susceptibility to ceftazidime, ceftriaxone, and cefotaxime contain an ampC gene that is preceded by a strong promoter. Transcription from the strong promoter was 8- to 18-fold higher than that from the promoter from a susceptible isolate. RNA studies showed that mRNA stability does not play a role in the control of AmpC synthesis. ...[more]

Similar Datasets

Unknown Community Emergence of Cefixime-Resistant <i>Escherichia coli</i> Belonging to ST12 with Chromosomal AmpC Hyperproduction.
| S-EPMC10967553 | biostudies-literature
Unknown Molecular mechanisms of beta-lactam resistance mediated by AmpC hyperproduction in Pseudomonas aeruginosa clinical strains.
| S-EPMC1280133 | biostudies-literature
Unknown A 100 Clinical Isolates of Escherichia coli
| S-MBRS6 | biostudies-other
Unknown Molecular analysis of AmpC-producing Escherichia coli isolated from pediatric patients.
| S-EPMC11949381 | biostudies-literature
Unknown High prevalence of multidrug resistant ESBL- and plasmid mediated AmpC-producing clinical isolates of Escherichia coli at Maputo Central Hospital, Mozambique.
| S-EPMC7789290 | biostudies-literature
Unknown Overproduction of Chromosomal <i>ampC</i> β-Lactamase Gene Maintains Resistance to Cefazolin in Escherichia coli Isolates.
| S-EPMC9241650 | biostudies-literature
Unknown Molecular basis of virulence in clinical isolates of Escherichia coli and Salmonella species from a tertiary hospital in the Eastern Cape, South Africa.
| S-EPMC3125331 | biostudies-literature
Unknown Molecular characterization of enterohemorrhagic Escherichia coli isolates from cattle.
| S-EPMC4197144 | biostudies-literature
Unknown Extended-spectrum beta-lactamases and plasmid-mediated AmpC enzymes among clinical isolates of Escherichia coli and Klebsiella pneumoniae from seven medical centers in Taiwan.
| S-EPMC1472213 | biostudies-literature
Unknown AmpC beta-lactamase in an Escherichia coli clinical isolate confers resistance to expanded-spectrum cephalosporins.
| S-EPMC521871 | biostudies-literature