High RRM2 expression has poor prognosis in specific types of breast cancer.

ABSTRACT:

Background

RRM2 plays an important role in different malignant tumors, but there are few studies in breast cancer. Public databases were used to analyze the expression of RRM2 in breast cancer and its prognostic value.

Materials and methods

A total of 2,509 breast cancer samples were downloaded from the METABRIC database. The relationship between RRM2 expression and clinical pathology was evaluated. Using the BCIP database and real-time-PCR, and western blotting, RRM2 mRNA and protein expression of RRM2 in breast cancer tissues and cell lines were evaluated. Univariate and multivariate analysis defined independent prognostic factors that affected the overall survival of patients with breast cancer. The Kaplan-Meier method was used to study the relationship between the high e

SUBMITTER: Shi SC 

PROVIDER: S-EPMC8923511 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature