Tissue-resident macrophages provide a pro-tumorigenic niche to early NSCLC cells.

ABSTRACT: Macrophages have a key role in shaping the tumour microenvironment (TME), tumour immunity and response to immunotherapy, which makes them an important target for cancer treatment^1,2. However, modulating macrophages has proved extremely difficult, as we still lack a complete understanding of the molecular and functional diversity of the tumour macrophage compartment. Macrophages arise from two distinct lineages. Tissue-resident macrophages self-renew locally, independent of adult haematopoiesis^3-5, whereas short-lived monocyte-derived macrophages arise from adult haematopoietic stem cells, and accumulate mostly in inflamed lesions¹. How these macrophage lineages contribute to the TME and cancer progression remains unclear. To explore the diversity of the mac

SUBMITTER: Casanova-Acebes M 

PROVIDER: S-EPMC8923521 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature