SOX4 facilitates PGR protein stability and FOXO1 expression conducive for human endometrial decidualization.

ABSTRACT: The establishment of pregnancy in human necessitates appropriate decidualization of stromal cells, which involves steroids regulated periodic transformation of endometrial stromal cells during the menstrual cycle. However, the potential molecular regulatory mechanism underlying the initiation and maintenance of decidualization in humans is yet to be fully elucidated. In this investigation, we document that SOX4 is a key regulator of human endometrial stromal cells decidualization by directly regulating FOXO1 expression as revealed by whole genomic binding of SOX4 assay and RNA sequencing. Besides, our immunoprecipitation and mass spectrometry results unravel that SOX4 modulates progesterone receptor (PGR) stability through repressing E3 ubiquitin ligase HERC4-mediated degradation. More imp

SUBMITTER: Huang P 

PROVIDER: S-EPMC8923662 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature