Increasing application of pediatric physiologically based pharmacokinetic models across academic and industry organizations.

ABSTRACT: There has been a significant increase in the use of physiologically based pharmacokinetic (PBPK) models during the past 20 years, especially for pediatrics. The aim of this study was to give a detailed overview of the growth and areas of application of pediatric PBPK (P-PBPK) models. A total of 181 publications and publicly available regulatory reviews were identified and categorized according to year, author affiliation, platform, and primary application of the P-PBPK model (in clinical settings, drug development or to advance pediatric model development in general). Secondary application areas, including dose selection, biologics, and drug interactions, were also assessed. The growth rate for P-PBPK modeling increased 33-fold between 2005 and 2020; this was mainly attributed to growth in

SUBMITTER: Johnson TN 

PROVIDER: S-EPMC8923731 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature