Predicting model-informed precision dosing: A test-case in tacrolimus dose adaptation for kidney transplant recipients.

ABSTRACT: Before investing resources into the development of a precision dosing (model-informed precision dosing [MIPD]) tool for tacrolimus, the performance of the tool was evaluated in silico. A retrospective dataset of 315 de novo kidney transplant recipients was first used to identify a one-compartment pharmacokinetic (PK) model with time-dependent clearance. MIPD performance was subsequently evaluated by calculating errors to predict future concentrations, which is directly related to dosing precision and probability of target attainment (PTA). Based on the identified model residual error, the theoretical upper limit was 45% PTA for a target of 13.5 ng/ml and an acceptable range of 12-15 ng/ml. Using empirical Bayesian estimation, this limit was reached on day 5 post-transplant and beyond. By i

SUBMITTER: Faelens R 

PROVIDER: S-EPMC8923732 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature