Changes in OGTT-derived biomarkers in response to lifestyle intervention among Latino adolescents with obesity.

ABSTRACT:

Background

Glucose concentrations during an oral glucose tolerance test (OGTT) have been used as biomarkers to differentiate type 2 diabetes risk phenotypes. No studies have examined changes in OGTT-glucose phenotypes following lifestyle intervention among high-risk youth.

Objective

To examine changes in OGTT-glucose phenotypes following lifestyle intervention and to explore differences in insulin sensitivity and β-cell function among post-intervention phenotypes.

Methods

Latino adolescents with obesity (n = 48, age 15.4 ± 1.0, BMI% 98.2 ± 1.4, female 56.3%) completed a 12-week lifestyle intervention that included weekly nutrition education and physical activity. At baseline and 12 weeks, youth completed a 2-h OGTT with glucose and insulin concentrations assessed at 0

SUBMITTER: Pena A 

PROVIDER: S-EPMC8923905 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature