Chemical synthesis, biological activities and action on nuclear receptors of 20S(OH)D₃, 20S,25(OH)₂D₃, 20S,23S(OH)₂D₃ and 20S,23R(OH)₂D₃.

ABSTRACT: New and more efficient routes of chemical synthesis of vitamin D₃ (D₃) hydroxy (OH) metabolites, including 20S(OH)D₃, 20S,23S(OH)₂D₃ and 20S,25(OH)₂D₃, that are endogenously produced in the human body by CYP11A1, and of 20S,23R(OH)₂D₃ were established. The biological evaluation showed that these compounds exhibited similar properties to each other regarding inhibition of cell proliferation and induction of cell differentiation but with subtle and quantitative differences. They showed both overlapping and differential effects on T-cell immune activity. They also showed similar interactions with nuclear receptors with all secosteroids activating vitamin D, liver X, retinoic acid orphan and aryl

SUBMITTER: Brzeminski P 

PROVIDER: S-EPMC8923993 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature