Helicobacter pylori Infection of Primary Human Monocytes Boosts Subsequent Immune Responses to LPS.

ABSTRACT: Infection with Helicobacter pylori (H. pylori) affects almost half of the world's population and is a major cause of stomach cancer. Although immune cells react strongly to this gastric bacterium, H. pylori is still one of the rare pathogens that can evade elimination by the host and cause chronic inflammation. In the present study, we characterized the inflammatory response of primary human monocytes to repeated H. pylori infection and their responsiveness to an ensuing bacterial stimulus. We show that, although repeated stimulations with H. pylori do not result in an enhanced response, H. pylori-primed monocytes are hyper-responsive to an Escherichia coli-lipopolysaccharide (LPS) stimulation that takes place shortly after infection. This hyper-re

SUBMITTER: Frauenlob T 

PROVIDER: S-EPMC8924073 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature