Human Coxsackie- and adenovirus receptor is a putative target of neutrophil elastase-mediated shedding.

ABSTRACT:

Background

During viral-induced myocarditis, immune cells migrate towards the site of infection and secrete proteases, which in turn can act as sheddases by cleaving extracellular domains of transmembrane proteins. We were interested in the shedding of the Coxsackie- and adenovirus receptor (CAR) that acts as an entry receptor for both eponymous viruses, which cause myocarditis. CAR shedding by secreted immune proteases could result in a favourable outcome of myocarditis as CAR's extracellular domain would be removed from the cardiomyocytes' surface leading to decreased susceptibility to ongoing viral infections.

Methods and results

In this work, matrix metalloproteinases and serine proteinases were screened for their proteolytic activity towards human CAR. Whereas matrix me

SUBMITTER: Herrmann L 

PROVIDER: S-EPMC8924087 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature