Systematic review of the receptor tyrosine kinase superfamily in neuroblastoma pathophysiology.

ABSTRACT:

Background

Neuroblastoma is a devastating disease accounting for 15% of all childhood cancer deaths. Yet, our understanding of key molecular drivers such as receptor tyrosine kinases (RTKs) in this pathology remains poorly clarified. Here, we provide a systematic analysis of the RTK superfamily in the context of neuroblastoma pathogenesis.

Methods

Statistical correlations for all RTK family members' expression to neuroblastoma patient survival across 10 independent patient cohorts were annotated, synthesized, and ranked using the R2: Genomics Analysis and Visualization Platform. Gene expression of selected members across different cancer cell lines was further analyzed in the Cancer Cell Line Encyclopedia, part of the Cancer Dependency Map portal (depmap portal ( http://depm

SUBMITTER: Rozen EJ 

PROVIDER: S-EPMC8924100 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature