Ontology highlight
ABSTRACT:
SUBMITTER: Duan J
PROVIDER: S-EPMC8924211 | biostudies-literature | 2022 Mar
REPOSITORIES: biostudies-literature
Duan Jia J Shen Dan-Dan DD Zhao Tingting T Guo Shimeng S He Xinheng X Yin Wanchao W Xu Peiyu P Ji Yujie Y Chen Li-Nan LN Liu Jinyu J Zhang Huibing H Liu Qiufeng Q Shi Yi Y Cheng Xi X Jiang Hualiang H Eric Xu H H Zhang Yan Y Xie Xin X Jiang Yi Y
Nature communications 20220315 1
Peptide hormones and neuropeptides are complex signaling molecules that predominately function through G protein-coupled receptors (GPCRs). Two unanswered questions remaining in the field of peptide-GPCR signaling systems pertain to the basis for the diverse binding modes of peptide ligands and the specificity of G protein coupling. Here, we report the structures of a neuropeptide, galanin, bound to its receptors, GAL1R and GAL2R, in complex with their primary G protein subtypes G<sub>i</sub> an ...[more]