Measuring mechanical anisotropy of the cornea with Brillouin microscopy.

ABSTRACT: Load-bearing tissues are typically fortified by networks of protein fibers, often with preferential orientations. This fiber structure imparts the tissues with direction-dependent mechanical properties optimized to support specific external loads. To accurately model and predict tissues' mechanical response, it is essential to characterize the anisotropy on a microstructural scale. Previously, it has been difficult to measure the mechanical properties of intact tissues noninvasively. Here, we use Brillouin optical microscopy to visualize and quantify the anisotropic mechanical properties of corneal tissues at different length scales. We derive the stiffness tensor for a lamellar network of collagen fibrils and use angle-resolved Brillouin measurements to determine the longitudinal stiffnes

SUBMITTER: Eltony AM 

PROVIDER: S-EPMC8924229 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature