Kinetic interplay between droplet maturation and coalescence modulates shape of aged protein condensates.

ABSTRACT: Biomolecular condensates formed by the process of liquid-liquid phase separation (LLPS) play diverse roles inside cells, from spatiotemporal compartmentalisation to speeding up chemical reactions. Upon maturation, the liquid-like properties of condensates, which underpin their functions, are gradually lost, eventually giving rise to solid-like states with potential pathological implications. Enhancement of inter-protein interactions is one of the main mechanisms suggested to trigger the formation of solid-like condensates. To gain a molecular-level understanding of how the accumulation of stronger interactions among proteins inside condensates affect the kinetic and thermodynamic properties of biomolecular condensates, and their shapes over time, we develop a tailored coarse-grained model

SUBMITTER: Garaizar A 

PROVIDER: S-EPMC8924231 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature