Simultaneous assessment of spontaneous cage activity and voluntary wheel running in group-housed mice.

ABSTRACT: Small animal models are frequently used to improve our understanding of the molecular and biological signaling pathways underlying the beneficial effects of physical activity and exercise. Unfortunately, when running wheels are employed, mice and rats are often kept single-housed to determine the individual running distance of each animal. However, social isolation can be stressful for rodents, and may alter an individual's propensity for or response to exercise. For example, increased stress from single housing may significantly affect the results when investigating systemic metabolic responses to exercise. We have combined two already available and well-established systems, a radiotelemetry system and a running wheel, to determine spontaneous cage activity (SCA) as well as voluntary exer

SUBMITTER: Reuser A 

PROVIDER: S-EPMC8924253 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature