Functional magnetic resonance imaging data for the association between polygenic risk scores for neuroticism and reward-punishment processing.

ABSTRACT: Neuroticism as a personality trait represents a heritable risk for psychiatric disorders. The polygenic risk score for neuroticism (N-PRS) is used to study genetic vulnerability to neuroticism. The current data present the association of the genetic risk for neuroticism to neural reward-punishment processing using functional magnetic resonance imaging. N-PRS was computed based on the individual's genotype information and a genome-wide association study on the UK Biobank data. While individuals performed a monetary incentive delay task, their neural activations for upcoming incentives (reward: gain, punishment: loss) were measured in blood oxygen level dependent (BOLD) signals during the delay phase. Multivariate ANCOVAs were used to analyze BOLD signals for finding the association between

SUBMITTER: Park H 

PROVIDER: S-EPMC8924281 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature