UPMaBoSS: A Novel Framework for Dynamic Cell Population Modeling.

ABSTRACT: Mathematical modeling aims at understanding the effects of biological perturbations, suggesting ways to intervene and to reestablish proper cell functioning in diseases such as cancer or in autoimmune disorders. This is a difficult task for obvious reasons: the level of details needed to describe the intra-cellular processes involved, the numerous interactions between cells and cell types, and the complex dynamical properties of such populations where cells die, divide and interact constantly, to cite a few. Another important difficulty comes from the spatial distribution of these cells, their diffusion and motility. All of these aspects cannot be easily resolved in a unique mathematical model or with a unique formalism. To cope with some of these issues, we introduce here a novel framewor

SUBMITTER: Stoll G 

PROVIDER: S-EPMC8924294 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature