Comparative Genomics of the Major Histocompatibility Complex (MHC) of Felids.

ABSTRACT: This review summarizes the current knowledge on the major histocompatibility complex (MHC) of the family Felidae. This family comprises an important domestic species, the cat, as well as a variety of free-living felids, including several endangered species. As such, the Felidae have the potential to be an informative model for studying different aspects of the biological functions of MHC genes, such as their role in disease mechanisms and adaptation to different environments, as well as the importance of genetic diversity for conservation issues in free-ranging or captive populations. Despite this potential, the current knowledge on the MHC in the family as a whole is fragmentary and based mostly on studies of the domestic cat and selected species of big cats. The overall structure of the

SUBMITTER: Plasil M 

PROVIDER: S-EPMC8924298 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature