Synbiotic goat milk kefir improves health status in rats fed a high-fat and high-fructose diet.

ABSTRACT:

Background and aim

Kefir, a natural probiotic containing bacteria and yeast, is a fermented milk product, whereas glucomannan from porang tuber (Amorphophallus oncophyllus) is prebiotic in vivo. Simvastatin is a potent lipid-lowering statin that can be utilized for pharmacological therapy in obesity. This study aimed to determine the effect of goat milk kefir supplemented with porang glucomannan (synbiotic kefir) and goat milk kefir without glucomannan (probiotic kefir) on blood glucose, hemoglobin A1c (HbA1c), free fatty acids (FFAs), tumor necrosis factor-alpha (TNF-α), gene expression of peroxisome proliferator-activated receptor gamma (PPARg), and insulin-producing cells in rats fed a high-fat and high-fructose (HFHF) diet.

Materials and methods

Male Spragu

SUBMITTER: Nurliyani N 

PROVIDER: S-EPMC8924388 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature