GOing Forward With the Cardiac Conduction System Using Gene Ontology.

ABSTRACT: The cardiac conduction system (CCS) comprises critical components responsible for the initiation, propagation, and coordination of the action potential. Aberrant CCS development can cause conduction abnormalities, including sick sinus syndrome, accessory pathways, and atrioventricular and bundle branch blocks. Gene Ontology (GO; http://geneontology.org/) is an invaluable global bioinformatics resource which provides structured, computable knowledge describing the functions of gene products. Many gene products are known to be involved in CCS development; however, this information is not comprehensively captured by GO. To address the needs of the heart development research community, this study aimed to describe the specific roles of proteins reported in the literature to be involved with CC

SUBMITTER: Chloe Li KY 

PROVIDER: S-EPMC8924464 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature