Urinary sodium excretion and the risk of CVD: a community-based cohort study in Taiwan.

ABSTRACT: Urinary Na excretion is a potential risk factor for CVD. However, the underlying biological mechanisms and effects of salt sensitivity are unclear. The purpose of this study was to characterise the relative contribution of biological factors to the Na-CVD association. A total of 2112 participants were enrolled in this study. Structured questionnaires and blood and urine samples were obtained. Twenty-four-hour Na excretion was estimated using a single overnight urine sample. Hypertension, the metabolic syndrome and overweight status were considered to indicate salt sensitivity. Cox proportional hazard models were used to investigate the effects of salt sensitivity on urinary Na excretion and CVD risk. The traditional mediation approach was used to calculate the proportion of mediation. The

SUBMITTER: Wang YJ 

PROVIDER: S-EPMC8924491 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature