Comprehensive characterization of human-virus protein-protein interactions reveals disease comorbidities and potential antiviral drugs.

ABSTRACT: The protein-protein interactions (PPIs) between human and viruses play important roles in viral infection and host immune responses. Rapid accumulation of experimentally validated human-virus PPIs provides an unprecedented opportunity to investigate the regulatory pattern of viral infection. However, we are still lack of knowledge about the regulatory patterns of human-virus interactions. We collected 27,293 experimentally validated human-virus PPIs, covering 8 virus families, 140 viral proteins and 6059 human proteins. Functional enrichment analysis revealed that the viral interacting proteins were likely to be enriched in cell cycle and immune-related pathways. Moreover, we analysed the topological features of the viral interacting proteins and found that they were likely to locate in ce

SUBMITTER: Li S 

PROVIDER: S-EPMC8924640 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature