Identifying Changes of Brain Regional Homogeneity and Cingulo-Opercular Network Connectivity in First-Episode, Drug-Naive Depressive Patients With Suicidal Ideation.

ABSTRACT:

Objective

Adult patients with major depressive disorder (MDD) may not actively reveal their suicidal ideation (SI). Therefore, this study is committed to finding the alterations in the cingulo-opercular network (CON) that are closely related to SI with multi-imaging methods, thus providing neuroimaging basis for SI.

Method

A total of 198 participants (129 MDD patients and 69 healthy controls) were recruited and evaluated with the Montgomery-Asberg Depression Rating Scale (MADRS). The healthy individuals formed the HC group, while the MDD patients were subdivided into no SI MDD (NSI, n = 32), mild SI MDD (MSI, n = 64), and severe SI MDD (SSI, n = 33) according to their MADRS item 10. We obtained MRI data of all participants and applied regional homogeneit

SUBMITTER: He M 

PROVIDER: S-EPMC8924659 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature