Fantastic [FeFe]-Hydrogenases and Where to Find Them.

ABSTRACT: [FeFe]-hydrogenases are complex metalloenzymes, key to microbial energy metabolism in numerous organisms. During anaerobic metabolism, they dissipate excess reducing equivalents by using protons from water as terminal electron acceptors, leading to hydrogen production. This reaction is coupled to reoxidation of specific redox partners [ferredoxins, NAD(P)H or cytochrome c₃], that can be used either individually or simultaneously (via flavin-based electron bifurcation). [FeFe]-hydrogenases also serve additional physiological functions such as H₂ uptake (oxidation), H₂ sensing, and CO₂ fixation. This broad functional spectrum is enabled by a modular architecture and vast genetic diversity, which is not fully explored and understood. This Min

SUBMITTER: Morra S 

PROVIDER: S-EPMC8924675 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature