Predicting Probability of Response to Tumor Necrosis Factor Inhibitors for Individual Patients With Ankylosing Spondylitis.

ABSTRACT:

Importance

Tumor necrosis factor inhibitors (TNFis) have revolutionized the management of ankylosing spondylitis (AS); however, the lack of notable clinical responses in approximately one-half of patients suggests important heterogeneity in treatment response. Identifying patients likely to respond or not respond to TNFis could provide opportunities to personalize treatment strategies.

Objective

To develop models of the probability of short-term response to TNFi treatment in individual patients with active AS.

Design, setting, and participants

This is a retrospective cohort study using data of the TNFi group (ie, treatment group) from 10 randomized clinical trials (RCTs) of TNFi treatment among patients with active AS, conducted from 2002 to 2016. Participants were ad

SUBMITTER: Wang R 

PROVIDER: S-EPMC8924712 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature