Adaptive Recombinant Nanoworms from Genetically Encodable Star Amphiphiles.

ABSTRACT: Recombinant nanoworms are promising candidates for materials and biomedical applications ranging from the templated synthesis of nanomaterials to multivalent display of bioactive peptides and targeted delivery of theranostic agents. However, molecular design principles to synthesize these assemblies (which are thermodynamically favorable only in a narrow region of the phase diagram) remain unclear. To advance the identification of design principles for the programmable assembly of proteins into well-defined nanoworms and to broaden their stability regimes, we were inspired by the ability of topologically engineered synthetic macromolecules to acess rare mesophases. To test this design principle in biomacromolecular assemblies, we used post-translational modifications (PTMs) to generate lip

SUBMITTER: Hossain MS 

PROVIDER: S-EPMC8924867 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature