Protective Effects of Naringenin from Citrus sinensis (var. Valencia) Peels against CCl₄-Induced Hepatic and Renal Injuries in Rats Assessed by Metabolomics, Histological and Biochemical Analyses.

ABSTRACT: Citrus fruits are grown worldwide for their special nutritive and several health benefits. Among citrus bioactives, naringenin, a major flavanone, exhibits a potential hepatoprotective effect that is not fully elucidated. Herein, serum biochemical parameters and histopathological assays were used to estimate the hepatoprotective activity of naringenin, isolated from Citrus sinensis (var. Valencia) peels, in CCl₄-induced injury in a rat model. Further, GC-MS-based untargeted metabolomics was used to characterize the potential metabolite biomarkers associated with its activity. Present results revealed that naringenin could ameliorate the increases in liver enzymes (ALT and AST) induced by CCl₄ and attenuate the pathological changes in liver tissue. Naring

SUBMITTER: Ammar NM 

PROVIDER: S-EPMC8924893 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature