Measurement harmonization and traceability for trace element analyses across the Children's Health Exposure Analysis Resource laboratory network.

ABSTRACT: Harmonization and traceability are related metrological principles that are indispensable to assuring measurement comparability across different biomonitoring studies. The Children's Health Exposure Analysis Resource (CHEAR) was established in 2015 with six laboratories providing environmental exposure measurements on biospecimens. To ensure harmonization across studies for trace elements, CHEAR used a multi-faceted approach that included: 1) an initial interlaboratory validation exercise based on the analysis of certified blood and urine reference materials; 2) frequent participation in an established interlaboratory proficiency program for trace elements; and 3) analysis of a common pool of well-characterized biological reference materials with each analytical batch. Method accuracy and

SUBMITTER: Galusha AL 

PROVIDER: S-EPMC8924990 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature