Peripheral Immune Cell Numbers and C-Reactive Protein in Parkinson's Disease: Results from a Population-Based Study.

ABSTRACT:

Background

The immune system is known to be involved in Parkinson's disease (PD) pathogenesis, but the temporal relationship between peripheral immune responses and PD remains unknown.

Objective

We determined the association between peripheral immune cell numbers, C-reactive protein (CRP), and prevalent as well as incident PD.

Methods

This study was embedded in the population-based setting of the Rotterdam Study. We repeatedly measured peripheral immune cell numbers (differential leukocyte count and platelet count, granulocyte-to-lymphocyte ratio [GLR], platelet-to-lymphocyte ratio [PLR], and adapted systemic immune-inflammation index [adapted SII]) and CRP between 1990 and 2016. Participants were continuously followed-up for PD until 2018. We estimated the associatio

SUBMITTER: Dommershuijsen LJ 

PROVIDER: S-EPMC8925126 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature