A-Prot: protein structure modeling using MSA transformer.

ABSTRACT:

Background

The accuracy of protein 3D structure prediction has been dramatically improved with the help of advances in deep learning. In the recent CASP14, Deepmind demonstrated that their new version of AlphaFold (AF) produces highly accurate 3D models almost close to experimental structures. The success of AF shows that the multiple sequence alignment of a sequence contains rich evolutionary information, leading to accurate 3D models. Despite the success of AF, only the prediction code is open, and training a similar model requires a vast amount of computational resources. Thus, developing a lighter prediction model is still necessary.

Results

In this study, we propose a new protein 3D structure modeling method, A-Prot, using MSA Transformer, one of the state-of-the-art pr

SUBMITTER: Hong Y 

PROVIDER: S-EPMC8925138 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature