LncRNA PTCSC3 is upregulated in osteoporosis and negatively regulates osteoblast apoptosis.

ABSTRACT:

Background

It is known that long non-coding RNA (lncRNA) PTCSC3 is involved in thyroid cancer and glioma, but its function in osteoporosis is unknown. The aim of our study was to investigate the role of lncRNA PTCSC3 in osteoporosis.

Methods

A total of 80 patients with osteoporosis (4 clinical stages) and four corresponding groups of healthy controls were enrolled. Plasma PTCSC3 levels in the 80 osteoporosis patients and 80 healthy volunteers were measured using RT-qPCR. The diagnostic potential of plasma PTCSC3 for osteoporosis was evaluated by ROC curve analysis with healthy volunteers as the true negative cases and corresponding osteoporosis patients as the true positive cases.

Results

PTCSC3 was upregulated in osteoporosis patients compared with healthy controls.

SUBMITTER: Liu X 

PROVIDER: S-EPMC8925152 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature