The impact of AMIGO2 on prognosis and hepatic metastasis in gastric cancer patients.

ABSTRACT:

Background

Gastric cancer (GC) is one of the most common malignancies, and the liver is the most common site of hematogenous metastasis of GC. AMIGO2 is a type I transmembrane protein that has been implicated in tumour cell adhesion in adenocarcinomas; however, its importance in GC remains undetermined.

Methods

We analyzed AMIGO2 expression by immunohistochemistry using the specific monoclonal antibody for human AMIGO2 in 128 patients who underwent GC surgery to evaluate its relationship between various metastatic and clinical outcomes in GC.

Results

Immunohistochemistry revealed that AMIGO2 expression was an independent prognostic factor for overall survival, disease-specific survival, and liver metastasis in GC patients.

Conclusions

This study showed that AMI

SUBMITTER: Goto K 

PROVIDER: S-EPMC8925171 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature