Transcriptomic and metabolomic associations with exposures to air pollutants among young adults with childhood asthma history.

ABSTRACT: Ambient air pollutants are well-known risk factors for childhood asthma and asthma exacerbation. It is unknown whether different air pollutants individually or jointly affect pathophysiological mechanisms of asthma. In this study, we aim to integrate transcriptome and untargeted metabolome to identify dysregulated genetic and metabolic pathways that are associated with exposures to a mixture of ambient and traffic-related air pollutants among adults with asthma history. In this cross-sectional study, 102 young adults with childhood asthma history were enrolled from southern California in 2012. Whole blood transcriptome was measured with 20,869 expression signatures, and serum untargeted metabolomics including 937 metabolites were analyzed by Metabolon, Inc. Participants' exposures to regio

SUBMITTER: Liao J 

PROVIDER: S-EPMC8925195 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature