Associations between testosterone, estradiol, and androgen receptor genotype with amygdala subregions in adolescents.

ABSTRACT: Much is known about the development of the whole amygdala, but less is known about its structurally and functionally diverse subregions. One notable distinguishing feature is their wide range of androgen and estrogen receptor densities. Given the rise in pubertal hormones during adolescence, sex steroid levels as well as receptor sensitivity could influence age-related subregion volumes. Therefore, our goal was to evaluate the associations between the total amygdala and its subregion volumes in relation to sex hormones - estradiol and free testosterone (FT) - as a function of age and genetic differences in androgen receptor (AR) sensitivity in a sample of 297 adolescents (46% female). In males, we found small effects of FT-by-age interactions in the total amygdala, portions of the basolate

SUBMITTER: Campbell CE 

PROVIDER: S-EPMC8925279 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature