Neural Recruitment During Conventional, Burst, and 10-kHz Spinal Cord Stimulation for Pain.

ABSTRACT: Spinal cord stimulation (SCS) is a popular neurostimulation therapy for severe chronic pain. To improve stimulation efficacy, multiple modes are now used clinically, including conventional, burst, and 10-kHz SCS. Clinical observations have produced speculation that these modes target different neural elements and/or work via distinct mechanisms of action. However, in humans, these hypotheses cannot be conclusively answered via experimental methods. Therefore, we utilized computational modeling to assess the response of primary afferents, interneurons, and projection neurons to conventional, burst, and 10-kHz SCS. We found that local cell thresholds were always higher than afferent thresholds, arguing against direct recruitment of these local cells. Furthermore, although we observed relativ

SUBMITTER: Rogers ER 

PROVIDER: S-EPMC8925309 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature