Heritability of Coronary Artery Disease: Insights From a Classical Twin Study.

ABSTRACT:

Background

Genetics have a strong influence on calcified atherosclerotic plaques; however, data regarding the heritability of noncalcified plaque volume are scarce. We aimed to evaluate genetic versus environmental influences on calcium (coronary artery calcification) score, noncalcified and calcified plaque volumes by coronary computed tomography angiography in adult twin pairs without known coronary artery disease.

Methods

In the prospective BUDAPEST-GLOBAL (Burden of Atherosclerotic Plaques Study in Twins-Genetic Loci and the Burden of Atherosclerotic Lesions) classical twin study, we analyzed twin pairs without known coronary artery disease. All twins underwent coronary computed tomography angiography to assess coronary atherosclerotic plaque volumes. Structural equation

SUBMITTER: Drobni ZD 

PROVIDER: S-EPMC8925867 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature