Altered Intra- and Inter-Network Functional Connectivity in Patients With Crohn's Disease: An Independent Component Analysis-Based Resting-State Functional Magnetic Resonance Imaging Study.

ABSTRACT:

Background

Many studies have reported changes in the structure and function of several brain areas in patients with Crohn's disease (CD). However, little is known about whether the possible functional connectivity of resting-state networks (RSNs) is altered in CD patients.

Purpose

Aim to investigate the intra- and inter-network alterations between related RSNs in patients with CD and the potential relationships between altered neuroimaging and CD clinical indices.

Materials and methods

In this study, 20 CD patients and 22 age- and sex-matched healthy controls were included. All participants underwent functional magnetic resonance imaging examination. We used independent component analysis (ICA) to explore the changes in RSNs and evaluated functional connectivity betwe

SUBMITTER: Li L 

PROVIDER: S-EPMC8926075 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature