A novel series of putative Brugia malayi histone demethylase inhibitors as potential anti-filarial drugs.

ABSTRACT: Filariasis, caused by a family of parasitic nematodes, affects millions of individuals throughout the tropics and is a major cause of acute and chronic morbidity. Current drugs are largely used in mass drug administration programs aimed at controlling the spread of disease by killing microfilariae, larval forms of the parasite responsible for transmission from humans to humans through insect vectors with limited efficacy against adult parasites. Although these drugs are effective, in some cases there are toxic liabilities. In case of loiasis which is caused by the parasitic eyeworm Loa loa, mass drug administration is contraindicative due to severe side effects of microfilariae killing, which can be life threatening. Our screening program and medicinal chemistry efforts have led to the ide

SUBMITTER: Kreiss T 

PROVIDER: S-EPMC8926182 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature