Global dynamics of microbial communities emerge from local interaction rules.

ABSTRACT: Most microbes live in spatially structured communities (e.g., biofilms) in which they interact with their neighbors through the local exchange of diffusible molecules. To understand the functioning of these communities, it is essential to uncover how these local interactions shape community-level properties, such as the community composition, spatial arrangement, and growth rate. Here, we present a mathematical framework to derive community-level properties from the molecular mechanisms underlying the cell-cell interactions for systems consisting of two cell types. Our framework consists of two parts: a biophysical model to derive the local interaction rules (i.e. interaction range and strength) from the molecular parameters underlying the cell-cell interactions and a graph based model to

SUBMITTER: van Vliet S 

PROVIDER: S-EPMC8926250 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature