Methylation pattern of polymorphically imprinted nc886 is not conserved across mammalia.

ABSTRACT:

Background

In humans, the nc886 locus is a polymorphically imprinted metastable epiallele. Periconceptional conditions have an effect on the methylation status of nc886, and further, this methylation status is associated with health outcomes in later life, in line with the Developmental Origins of Health and Disease (DOHaD) hypothesis. Animal models would offer opportunities to study the associations between periconceptional conditions, nc886 methylation status and metabolic phenotypes further. Thus, we set out to investigate the methylation pattern of the nc886 locus in non-human mammals.

Data

We obtained DNA methylation data from the data repository GEO for mammals, whose nc886 gene included all three major parts of nc886 and had sequency similarity of over 80% with the hu

SUBMITTER: Kostiniuk D 

PROVIDER: S-EPMC8926257 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature