Information quantity for secondary structure propensities of protein subsequences in the Protein Data Bank.

ABSTRACT: Elucidating the principles of sequence-structure relationships of proteins is a long-standing issue in biology. The nature of a short segment of a protein is determined by both the subsequence of the segment itself and its environment. For example, a type of subsequence, the so-called chameleon sequences, can form different secondary structures depending on its environments. Chameleon sequences are considered to have a weak tendency to form a specific structure. Although many chameleon sequences have been identified, they are only a small part of all possible subsequences in the proteome. The strength of the tendency to take a specific structure for each subsequence has not been fully quantified. In this study, we comprehensively analyzed subsequences consisting of four to nine amino acid

SUBMITTER: Kondo R 

PROVIDER: S-EPMC8926306 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature