The relationship between MHC-peptide interaction and resistance to virus in chickens.

ABSTRACT:

Introduction

The MHC-peptide interaction has a subtle influence on host resistance to virus. This paper aims to study the relationship between MHC-peptide interaction and MHC-related virus-resistance.

Methods

By 3D homology modeling, the structure of chicken BF2 molecule BF2*0201 (PDB code: 4d0d) was studied and compared with the known structures of BF2 molecule BF2*0401 (PDB code: 4e0r) to elucidate the characteristics of BF2*0201-binding antigenic peptides.

Results

The results show that due to the amino acid difference between the two binding groove of 4e0r and 4d0d, the size of the binding groove of the two are 1130 ų and1380 ų respectively, indicating the amino acid species that 4e0r binding peptide has lower selectivity than 4d0d; and because of large side chai

SUBMITTER: Jin YC 

PROVIDER: S-EPMC8926493 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature