The impact of preformed donor-specific antibodies in living donor liver transplantation according to graft volume.

ABSTRACT:

Introduction

The roles of preformed anti-HLA donor-specific antibodies (DSAs) in liver transplantation remain controversial. We evaluated the impact of preformed DSAs in living donor liver transplantation.

Methods

Adults who underwent living donor liver transplantation (n = 175) in our institute were included in this study. Lymphocyte cytotoxicity test (LCT), flow cytometric crossmatch (FCXM), and single-antigen bead assays were performed.

Results

Among adult living donor liver transplantation recipients, 27 (16.5%) and 14 (8.5%) had pretransplant FCXM-positive findings and LCT-positive findings, respectively. FCXM-positive patients displayed a significantly worse 5-year graft survival rate (77.3%; vs. DSA-negative, 91.6%). Six of 14 LCT-positive patients exhibited gr

SUBMITTER: Goto R 

PROVIDER: S-EPMC8926496 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature