Review of MIS-C Clinical Protocols and Diagnostic Pathways: Towards a Consensus Algorithm.

ABSTRACT:

Background

The emergence of multisystem inflammatory syndrome in children (MIS-C) during the severe acute respiratory syndrome coronavirus 2 pandemic led to the development of institutional clinical pathways based on expert opinion. We assessed North American paediatric centres' adaptation to MIS-C and analysed the degree of agreement between algorithms on tiered clinical investigations.

Methods

This study evaluated MIS-C diagnostic algorithms from 50 tertiary centres developed between May 2020 and December 2021 in the United States and Canada obtained online and through colleagues in various institutions. Descriptive statistics were used to analyse results.

Results

All clinical pathways used a tiered approach, and most required coronavirus disease 2019 polymerase cha

SUBMITTER: Tritt A 

PROVIDER: S-EPMC8926880 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature